the prc2 complex sets long-term gene silencing through modification of histone tails
| PAG Title | the prc2 complex sets long-term gene silencing through modification of histone tails |
| PAG ID | WAG000028 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Packaging of D into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression. Recent studies have revealed that chromatin structure can be altered by covalent modification of nucleosomes, in particular acetylation and methylation of the core histone tails. Histone hyperacetylation usually characterizes active chromatin, while histone deacetylation correlates with repressed transcription. The Polycomb group (PcG) proteins are constituents of evolutiory highly conserved molecular pathways regulating cell fate in several tissues through diverse mechanisms, including 1) regulation of self-renewal/proliferation, 2) regulation of senescence/immortalization, 3) interaction with the initiation transcription machinery, 4) interaction with chromatin-condensation proteins, 5) modification of histones, 6) ictivation of paterl X chromosome, and 7) regulation of cell death. The PcG proteins form multimeric protein complexes, PRC1 and PRC2 which are involved in the heritablestable repression of genes through modification of chromatin structure. |
| Species | Homo sapiens |
| nCoCo Score | 3,699 |
| Base PAG ID | WAG000028 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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